With 16 teams, and the need for teams to have 3 home and homes, why not decide the home&home NFL style? The top 4 teams from the year before get each other twice (so you play the other 3 two times). Same for the next 4, and so on. You have 4 groups of 4. Boom. At least nobody can say that it favors certains teams. Yes, some good teams will be bad, and vice versa, but thats life. You play the 3 teams in your quadrant twice.
And when TCU becomes team 17? If they keep the same number of games, maybe divide into 3's and figure out the last 2 teams. Or, if they add one game to the BE schedule, maybe keep quads, and have some sort of designated rival. I dunno. Im not that smart and creative. It works easier with 16 teams.